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Correlation between serum calcium concentration and prognosis in patients with hypertensive intracerebral hemorrhage


  1. Department of Neurosurgery, the First People's Hospital of Lanzhou,   Lanzhou 730050,  China
  • Online:2019-02-20 Published:2019-02-20
  • Contact: Corresponding author: Zhang Zhenzhou, Email:

Abstract: Objective  To investigate the effect of serum calcium concentration on the prognosis of patients with hypertensive intracerebral hemorrhage(HICH). Methods  According to the blood calcium concentration measured at the admission, the patients were divided into three groups,  normal blood calcium group(n=145), hypocalcemia group(n=45) and hypercalcemia group(n=30). At the same time, baseline data and head CT/MRI scans were collected, and followup prognosis was assessed using Grasse Prognosis Scale(GCS). Multivariate logistic regression analysis was used to evaluate the effect of serum calcium concentration at admission on the prognosis of HICH. Results  The hypocalcemia group had a larger amount of hematoma, a lower GCS score,  a higher risk of hematoma breaking into the ventricle and rebleeding, and a higher proportion of patients requiring surgery. The proportion of poor prognosis(71.1%) was significantly higher than that of normal group (35.1%) and hypercalcemia group (33.3%)(P<0.05). Logistic regression analysis showed hypocalcemia is an independent risk factor affecting prognosis of HICH. Conclusion  HICH patients with hypocalcemia at admission are at high risk of critical illness and poor prognosis.

Key words: calcium;hypertension; , cerebral hemorrhage;prognosis