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Relationship between gross tumor volume and prognosis of patients with #br# esophageal cancer  detected by chest enhanced CT scan before radiotherapy

  

  1. Image Diagnosis Center,  Fushun General Hospital,  Liaoning Health Industry Group,  Fushun  113008, China
  • Online:2019-07-20 Published:2019-07-20
  • Contact: Corresponding author: Li Xinhai,Email: wbshen1979@sina.com

Abstract: Objective  To  investigate the relationship between gross tumor volume (GTVT) and prognosis of esophageal cancer patients undergoing radical radiotherapy detected by chest enhanced multislice spiral CT (MSCT) scan. Methods  A retrospective analysis  was performed in 392 patients with esophageal cancer who underwent radical radiotherapy. The relationship between GTVT and its clinical T stage and clinical TNM staging were analyzed. The relationship between GTVT and patient prognosis was analyzed.Results  The GTVT of the whole group was 7.55222.33 cm3 (median 45.88  cm3),  which was closely correlated with clinical T stage and TNM stage (r=0.673,  0.596,  P=0.000).According to the analysis result of ROC curve,  the best cutoff value was obtained when the value of GTVT  was 50.00  cm3.Multivariate analysis showed that the patients'  age,  clinical TNM staging and GTVT were independent factors affecting overall survival (OS)(P=0.000, 0.002, 0.014);  and the patients' lesion,  clinical TNM staging and GTVT was the independent factor influencing the patients' diseasefree survival (DFS)(P=0.020, 0.013, 0.006). Conclusion  The size of GTVT detected by chest MSCT scan before radiotherapy can predict the prognosis of esophageal cancer patients,  and the prognosis of patients with smaller GTVT is better.

Key words: esophageal neoplasms, radical radiotherapy, gross tumor volume, prognosis