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Analysis of prognostic value of hematological indexes in patients with malignant ascites

  

  1. Department of Gastroenterology,  Cangzhou Central Hospital,  Cangzhou 061001,China
  • Online:2019-09-20 Published:2019-09-20
  • Contact: Corresponding author:Zheng Guoqi, Email:czzxyyxhk@126.com

Abstract: Objective  To investigate the differences of the blood parameters in malignant ascites(MA),  and evaluate their influence on relationship with clinical prognosis. Methods  249 patients with pathologically proven MA were retrospectively reviewed. Investigation was performed in the changes of hematological indexes between MA group and control group,  also between malignant peritoneal mesothelioma(MPeM)   group and peritoneal carcinomatosis(PC) group. Age, sex, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) were analyzed.Influenceofblood lactic dehydrogenase(LDH), chemotherapy and viscera transfer on prognosis were analyzed.Results  Of the 249  MA patients who were initially difficult to identify benign/malignant ascites, MPeM accounted for 41%,  and PC accounted for 59%. The single factor analysis indicated that gender,  NLR,  PLR,  MLR,  LDH,  chemotherapy,  other organ metastasis were factors affecting  OS of MA patients,  but multivariate analysis indicated that LDH, other organ metastasis and NLR were independent factors  affecting  OS of MA patients.Conclusion  MA patients with lower LDH and NLR have a better prognosis. Early active treatment is of great significance for improving the survival rate of MA.

Key words: ascites, mesothelioma, neoplasmas, prognosis, laboratory techniques and procedures