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Efficacy  of  Zhenqi  Fuzheng  Capsule  combined with ursodeoxycholic acid on primary biliary cholangitis and its impact  on thyroid function

  

  1. Department of General Surgery,  Tianyou Hospital  affiliated to,  Tongji University,  Shanghai 200331, China
  • Online:2020-03-20 Published:2020-03-20
  • Contact: Corresponding author: Dai Dejian,Email: tianyoudaidejian@163.com

Abstract: Objective  To observe the efficacy of  Zhenqi Fuzheng Capsule  combined with ursodeoxycholic acid on primary bile cholangitis (PBC) and its impact on the thyroid function. Methods  A total of 70 PBC patients treated in our hospital were randomly divided into observation group and control group,  with 35 cases in each group.The control group was treated with ursodeoxycholic acid,  and the observation group was treated with Zhenqi Fuzheng Capsule combined with ursodeoxycholic acid. The level changes in two groups were observed before and after the treatment in order to compare the efficacy between two groups, including the levels of the alanine aminotransferase (ALT), aspartate aminotransferase (AST),  total bilirubin (TBIL),  alkaline phosphatase (ALP),  hyaluronan acid (HA), laminin(LN),  type Ⅲ  procollagen peptide (PCⅢ),  tissue inhibitor of metalloproteinase 1 (TIMP1),  total triiodothyronine (TT3),  free triiodothyroxine (FT3),  total thyroxine (TT4) and free thyroxine (FT4).Results  The total effective rate was 97.14% in observation group,  and that was 77.14%  in control group (P<0.05). After treatment,  the levels of serum ALT,  AST,   TBIL,  ALP,  HA,  TIMP1,  LN and PCⅢ  in two groups were significantly lower than those before treatment (P<0.01),  and the levels of serumTT3,  FT3,  TT4 and FT4 were significantly higher than those before treatment (P<0.01).The decrease or increase of level in observation group was more obvious than that in control group (P<0.01). Conclusion  Zhenqi Fuzheng Capsule combined with ursodeoxycholic acid has significant effecton PBC,  which can also improvethe fibrosis of the body and relievethe hypothyroidism.

Key words: drus, Chinese herbal; , cholangitis, thyroid function tests, liver cirrhosis