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Relationship between serum uric acid level and prognosis of  acute ischemic stroke: a metaanalysis

  

  1. 1.Hunan University of Chinese Medicine, Changsha 410208,China; 2.Department of Encephalopathy,
    Wuyi Hospital of Traditional Chinese Medicine Affiliated to Jinan University, Jiangmen 529000,China
  • Online:2020-08-20 Published:2020-08-20
  • Contact: Corresponding author: Lu Xiaoliang, Email:xiaolianglu@sina.com

Abstract: Objective  To evaluate the relationship between serum uric acid (SUA) level and the prognosis of acute ischemic stroke. Methods  Pubmed, Embase, Cochrane library databases were searched for the literatures  about the relationship between SUA level and the prognosis of acute ischemic stroke from inception to November 20,2019. The reference literatures were also consulted.The odds ratio(OR) of the prognosis of acute ischemic stroke per unit of SUA level in 95% confidence interval (95%CI) was collected.After evaluating the bias analysis of included studies,a metaanalysis was performed by Stata 16.0 software. Results  Fourteen studies involving 15 283 patients with acute ischemic stroke were included.Compared with the low SUA level, the high SUA level was  related to the good prognosis of acute ischemic stroke(OR=1.18,95%CI,1.101.26,P=0.006). Sensitivity analysis further identified the effects of SUA levels on the prognosis of acute ischemic stroke. Patients with good prognosis had a higher SUA level than those with poor prognosis. There was no obvious publication bias found in the metaanalysis. Conclusion  This metaanalysis supports that SUA level has a protective effect on neurological prognosis after acute ischemic stroke.

Key words: brain infarction, uric acid, prognosis, hyperuricemia, metaanalysis