Clinical Focus ›› 2016, Vol. 31 ›› Issue (3): 315-321.doi: 10.3969/j.issn.1004-583X.2016.03.020

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Association between mild cognitive impairment and apolipoprotein E genetic polymorphism in Chinese population: a meta-analysis

Zhang Jie, Zhou Xiaohui, Luo Kun   

  1. Department of Internal Medicine, the First Affiliated Hospital of Xinjiang University, Urumqi 830054, China
  • Received:2015-12-01 Online:2016-03-05 Published:2016-03-05
  • Contact: Zhou Xiaohui, Email:

Abstract: Objective To review systematically the correlation between genetic polymorphism of apolipoprotein E (ApoE) and mild cognitive impairment (MCI) in Chinese population.Methods A comprehensive search was conducted up between Jan 2005 and Mar 2015 in the following databases: PubMed, WanFang Database, VIP database, CNKI and Chinese biomedical literature database. The literature of correlation between genetic polymorphism of ApoE and mild cognitive impairment in Chinese population were collected. RevMan 5.0 was adopted for investigating heterogeneity among individual studies and for summarizing all the studies.Results There were totally 11 case-controlled studies including 1 416 patients with MCI and 1 183 control people. The meta-analysis showed that individuals with ApoE ε4 alleles and ε4/4, ε3/4, ε2/4 genotypes were significantly associated with the risk of MCI. Compared with genotype ε3/3, the MCI risk increased by 2.86 times in population with genotype ε4/4 (OR=2.86,95%CI=1.67-4.90,P<0.001); the MCI increased by 2.01 times in population with genotype ε3/4(OR=2.01,95%CI=1.70-2.38,P<0.001); the MCI risk increased by 1.71 times in t population with genotype ε2/4(OR=1.75,95%CI=1.21-2.53,P<0.001); Compared with genotype ε3, the MCI risk increased by 2.06 times (OR=2.06, 95%CI=1.69-2.51,P<0.001). The susceptibility to MCI in ApoE ε2/3 genotype was significantly decreased(ε2/3 vs ε3/3: OR=0.80, 95%CI=0.66-0.97,P=0.02). There were no significant difference between ApoE ε2/2 genotype, ε2 alleles and the onset risk of MCI.Conclusion ApoE ε4 alleles is related to the onset of MCI in Chinese population, ApoE ε3 alleles may be the protective gene of MCI and ApoE ε2 alleles shows no correlation with the onset of MCI.

Key words: mild cognitive impairment, apolipoproteins E, gene polymorphism, meta analysis

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