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Investigation of different vascular injuries  in newly diagnosed diabetic patients with Htype hypertension

  

  1. 1.Department of Endocrinology,Fengcheng Branch of Shanghai Ninth People's Hospital, Shanghai Jiaotong
    University School of Medicine, Shanghai 201411, China; 2.Department of Respiratory Medicine,
    Shanghai Jiaotong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China
  • Online:2017-03-05 Published:2017-03-05
  • Contact: Corresponding author:Huang Guolan,Email:junbowyg@163.com

Abstract: ObjectiveTo observe different vascular injuries  in diabetic patients with Htype hypertension.  MethodsA total of 379 patients with newly diagnosed T2DM were divided into three group according to whether with Htype hypertension: T2DM+Htype hypertension group (n=110), T2DM+nonHtype hypertension group (n=110) and T2DM group (n=159). The left ventricular structure, CIMT or with carotid atherosclerotic plaque formation were tested by ultrasonic cardiogram and color flow Doppler sonography. The LVMI, UAlb/UCr and CCr were counted. Results①The levels of SBP, DBP and Hcy in T2DM+Htype hypertension group and T2DM+nonHtype hypertension group were higher than those in T2DM group, HDLC was lower than that in T2DM group. Hcy level was higher in T2DM+Htype hypertension group than in T2DM+nonHtype hypertension group, and HDLC was significantly lower (P<0.05 or P<0.01); ②Compared with T2DM group, the rates of LVEF<50%, brian damage and IMT in T2DM+Htype hypertension group and T2DM+nonHtype hypertension group were significantly increased (P<0.05 or P<0.01), incidence of LVH and impaired renal function in T2DM+Htype hypertension were significantly increased (P<0.05 or P<0.01). The levels of LVMI, UAlb/UCr and CIMT in T2DM+Htype hypertension group and T2DM+nonHtype hypertension group were significantly higher than those in T2DM group, but the LVEF was significantly lower (P<0.05 or P<0.01), the levels of LVMI, CCr, UAlb/UCr and CIMT were significantly higher in T2DM+Htype hypertension group than those in T2DM+nonHtype hypertension group, and LVEF level was significantly lower (P<0.05).  ConclusionWhen patients are newly diagnosed with diabetes, vascular injury in different parts has formed, and Htype hypertension will aggravate the damage degree.

Key words: diabetes mellitus, type 2, hypertension, hyperhomocysteinemia;vascular system injuries