Clinical Focus ›› 2021, Vol. 36 ›› Issue (1): 35-38.doi: 10.3969/j.issn.1004-583X.2021.01.007

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Relationship between homocysteine and early neurological impairment severity and prognosis of acute cerebral infarction

Gong Tao1, Gao Yun1, Hu Yueyuan1, Wang Dongyu2()   

  1. 1. Graduate School of Jinzhou Medical University, Jinzhou 121000, China
    2. Department of Neurology, Jinzhou Central Hospital, Jinzhou 121000, China
  • Received:2020-09-08 Online:2021-01-20 Published:2021-01-14
  • Contact: Wang Dongyu


Objective Homocysteine(Hcy) serves as main risk factor for cerebral infarction, especially for large artery atherosclerosis (LAA) cerebral infarction. The relations between Hcy, severity and prognosis of early neurological impairment in patients with LAA were clinically studied. Methods A total of 260 patients with LAA acute cerebral infarction(ACI) were selected, the degree of neurological impairments of patients at admission was evaluated (mild NIHSS≤5 points, moderate to severe NIHSS>5 points) according to the National Institutes of Health Stroke Scale (NIHSS); the fasting serum Hcy level within 24 hours was tested, and the patients were divided into high Hcy group (Hcy≥10 μmol/L) and normal Hcy group (Hcy<10 μmol/L); the follow-up for 90 days was implemented to record the prognosis, the correlation between the serum Hcy level and severity or prognosis of early neurological impairments in ACI was analyzed. Results The serum Hcy level in patients with moderate or severe ACI was higher than that of patients with mild cerebral infarction (P<0.01); The serum Hcy level in patients with poor prognosis was significantly elevated (P<0.01), and binary logistic regression analysis showed that elevated Hcy level was an independent risk factor for higher severity of neurological impairments in early stages of ACI (P<0.01; OR=1.387, 95%Cl: 1.245-1.545) and an independent risk factor for poor prognosis (P<0.01; OR=1.478, 95%Cl: 1.312-1.666). Conclusion Elevated serum Hcy level may be an independent risk factor for early deterioration of neurological function and poor prognosis of LAA in ACI.

Key words: homocysteine, brain infarction, neurological deficit, prognosis

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