Clinical Focus ›› 2021, Vol. 36 ›› Issue (2): 101-106.doi: 10.3969/j.issn.1004-583X.2021.02.001

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Relationship between homocysteine and hypertensive disorder complicating pregnancy: a meta-analysis

Zhou Yixuan1, Lin Weizhao2, Li Ruiman2()   

  1. 1. The First Clinical Medical College of Jinan University, Guangzhou 510632, China
    2. Department of Obstetrics and Gynecology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • Received:2020-07-06 Online:2021-02-20 Published:2021-02-05
  • Contact: Li Ruiman


Objective To evaluate the correlation between plasma homocysteine (Hcy) levels and the risk of hypertensive disorder complicating pregnancy (HDCP). Methods PubMed, EMbase, Cochrane Library, Medline, Web of Science, CNKI, VIP and Wanfang data were searched for the literature which met inclusion and exclusion criteria. The quality evaluation of literature was carried out by Newcastle-Ottawa Scale. Rev Man 5.3 software was used to conduct meta-analysis. The included studies were analyzed to explore the correlation between plasma Hcy levels and risk of HDCP by the combination of the heterogeneity inspection and corresponding effect model. Results A total of 12 literature were included, all of which were of high quality (average score >5), with a total sample size of 10 079 cases. (1) The increase of plasma Hcy level was associated with the risk of HDCP(MD=4.44,95%CI: 3.01-5.87, P<0.01). (2)The plasma Hcy concentration in women with severe preeclampsia was higher than that in women with mild preeclampsia(MD=-2.84,95%CI:-3.78 - -1.90, P<0.01). (3) The correlation between serum folic acid and HDCP was statistically significant (MD=-3.21,95%CI:-4.50 - -1.91,P<0.01). (4) The correlation between serum Vit B12 level and HDCP was statistically significant (MD=-65.92,95%CI:-98.57 - -33.28, P<0.01). Conclusion Plasma Hcy level is closely related to the incidence of HDCP, its concentration is negatively correlated with serum levels of folic acid and Vit B12, and its expression level is significantly correlated with the severity of preeclampsia (PE). It is suggested that Hcy level may be a monitoring indicator for the efficacy and prognosis of PE.P

Key words: homocysteine, hypertension, pregnancy-induced, folic acid, Vit B12, meta-analysis

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