Clinical Focus ›› 2021, Vol. 36 ›› Issue (5): 389-394.doi: 10.3969/j.issn.1004-583X.2021.05.001

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Effects of HBV infection on liver metastasis of tumor: A meta-analysis

Wang Shimenga, Ma Yingjib, Wu Yinga, Liu Xiaodana, Wang Weia()   

  1. a. Department of Hematology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
    b. Department of Oncology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
  • Received:2020-10-11 Online:2021-05-20 Published:2021-05-31
  • Contact: Wang Wei


Objective To evaluate the effects of hepatitis-B virus (HBV) infection on various liver metastasis of tumors. Methods The published relevant literature on the effect of HBV on tumor liver metastasis were searched in PubMed, CNKI, and Wanfang Medical Database with the deadline dated on March 1, 2020. The studies on the incidence of liver metastasis in patients with HBV infection (infection group) and tumor patients without HBV infection (control group) were screened out. The quality evaluation on the literature was made, relevant data were extracted, and the meta-analysis was implemented with RevMan 5.3. Results A total of 22 articles were included. The risk of liver metastasis in patients complicated with HBV-infected tumors was significantly lower than in HBV-uninfected patients (OR=0.51, 95%CI 0.36-0.72,P<0.01). The studies on colon cancer, breast cancer, gastric cancer, and non-small cell lung cancer showed that combined HBV infection reduced the risk of liver metastasis(P<0.05), two literature reported liver metastasis of nasopharyngeal carcinoma risk, the patients with nasopharyngeal carcinoma with HBV infection had higher risk of liver metastasis (OR=3.37, 95%CI 1.84-6.19, P<0.01); two literature reported the risk of pancreatic cancer metastasis, HBV infection did not have significant effects on liver metastasis in patients with pancreatic cancer, and the difference was not statistically significant (P>0.05). Conclusion Combined HBV infection can reduce the incidence of liver metastases.

Key words: hepatitis B virus, tumor, liver metastasis, meta analysis

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