Clinical Focus ›› 2021, Vol. 36 ›› Issue (7): 620-622.doi: 10.3969/j.issn.1004-583X.2021.07.009

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Differential expression of IGF1R antisense noncoding RNA in hepatocellular carcinoma

Xie Zhihai1, Zhou Zhicong1, Gui Yuan2, Sun Jingfeng3()   

  1. 1. Geriatric Disease Treatment Center of Guangzhou Nursing Home, Guangzhou 510000, China
    2. Department of Hepatobiliary and Pancreatic Surgery, Jiangsu Cancer Hospital, Nanjing 210013, China
    3. Department of Oncology, the Fourth Affiliated Hospital of Nanjing Medical University, Nanjing 210013, China
  • Received:2021-01-26 Online:2021-07-20 Published:2021-07-23
  • Contact: Sun Jingfeng


Objective To detect the difference of insulin-like growth factor 1 receptor(IGF1R) antisense noncoding RNA(IGF1RAIN RNA) content between hepatocellular carcinoma and normal hepatic tissues, and to verify its possibility as a characteristic marker of hepatocellular carcinoma.Methods Reverse transcriptase polymerase chain reaction(RT-PCR) was used to detect the expression of IGF1RAIN RNA in 30 cases of hepatocellular carcinoma tissues, adjacent tissues and 16 cases of normal hepatic tissues(adjacent to the resection margin of hepatic hemangioma and hepatic cyst). Combined with the clinical and pathological data, the relationship between the content and hepatocellular cancer was analyzed.Results The content of IGF1RAIN RNA was significantly lower in hepatocellular cancer than that in normal hepatic tissues and adjacent tissues (P<0.05); IGF1RAIN RNA was different in tumor size, tumor differentiation and pathological stage(P<0.05).Conclusion The content of IGF1RAIN RNA was significantly decreased in hepatocellular cancer. It may be a marker for early diagnosis of hepatocellular cancer.

Key words: liver neoplasms, somatomedins, reverse transcriptase polymerase chain reaction, RNA

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