Clinical Focus ›› 2021, Vol. 36 ›› Issue (11): 972-975.doi: 10.3969/j.issn.1004-583X.2021.11.002

Previous Articles     Next Articles

Efficacy of magnesium isoglycyrrhizinate in anti-tuberculosis drug-induced liver injury

Yang Zhibin1a, Shao Yanfang1a, Pan Li1b, Yang Yanxia1a, Yang Yuxi1b, Zhao Lihui1a, Zeng Rongkun1a, Li Yang1a, Wang Qiaofeng1a, Wang Cong1a, Ma Shiwu2()   

  1. 1. a.Department of Infectious Diseases; b. Department of Laboratory, the Sixth Affiliated Hospital of Kunming Medical University (People's Hospital of Yuxi), Yuxi 653100, China
    2. Department of Infectious Diseases, 920 Hospital of Joint Logistic Support Force of PLA, Kunming 650032, China
  • Received:2021-08-02 Online:2021-11-20 Published:2021-12-01
  • Contact: Ma Shiwu


Objective To explore the efficacy of magnesium isoglycyrrhizinate(MgIG) in the treatment of anti-tuberculosis drug-induced liver injury (AT-DILI) and influence on cytokines (IFN-γ, IL-10, TNF-α).Methods The study enrolled 50 patients with mild hepatocellular injury who admitted to Infection Department, the Sixth Affiliated Hospital of Kunming Medical University from February 2016 to December 2019, and the patients met the criteria of AT-DILI. Patients were randomly grouped, 25 patients in observation group treated with MgIG, 25 patients in control group with polyene phosphatidylcholine(PPC). The key observation was liver function (ALT, AST, TBIL) and cytokine levels (IFN-γ, IL-10, TNF-α).Results The total effective rates were significantly higher in observation group than in control group (100% vs 76.0%, P<0.01). Compared with before treatment, IFN-γ, IL-10, and TNF-α in both groups were lower after treatment (all P<0.05), and the indexes were significantly decreased in observation group (all P<0.05). Pearson correlation analysis showed the cytokine levels were positively correlated with ALT in both groups at different time points.Conclusion MgIG can quickly improve liver function in mild AT-DILI, which may relate to the reduction of inflammatory cytokines.

Key words: chemical and drug induced liver injury, antituberculosis drugs, magnesium isoglycyrrhizinate, polyene phosphatidylcholine, cytokines

CLC Number: