Clinical Focus ›› 2022, Vol. 37 ›› Issue (4): 325-328.doi: 10.3969/j.issn.1004-583X.2022.04.007

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The relationship between serum homocysteine levels and SYNTAX score in patients with non-ST-segment elevation myocardial infarction

Wang Yajie, Lin Wenhua(), Jing Rui, Liu Jingjing, Lu Yujie   

  1. First department of internal medicine, TEDA International Cardiovascular Hospital, Tianjin 300457, China
  • Received:2021-09-16 Online:2022-04-20 Published:2022-05-13
  • Contact: Lin Wenhua


Objective To explore the relationship between serum homocysteine(HCY) levels and SYNTAX score(SS) in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Methods We performed a retrospective analysis of 298 patients with NSTEMI from the aspects of general clinical features, multiple laboratory indicators including serum HCY level, left ventricular ejection fraction (LVEF) and SS on the echocardiography during hospitalization. SS was also calculated according to the images of angiography for further statistical analysis. The patients were divided into three groups according to the SS value: low- (SS≤22), medium- (22<SS<33),high-SS group(SS≥33), with a comparison of interclass correlation from related data. Results The enrolled 298 NSTEMI patients consisted of 177 patients (59.4%) in the low-SS group, 77 (25.8%) in the medium-SS group, and 44 (14.8%) in the high-SS group. Serum HCY levels were (16.1±9.1) μmol/L, (20.3±9.1) μmol/L, (27.5±9.5) μmol/L in low-, medium-, and high-SS groups, respectively. Serum HCY levels in medium-, high-SS groups were significantly higher than those in low-SS group (P<0.01). The related analysis indicated homocysteine levels were correlated with SS (r=0.358, P<0.01). Conclusion Serum HCY levels were associated with increasing severity of coronary artery disease in the patients with NSTEMI.

Key words: non-ST-segment elevation myocardial infarction, homocysteine, SYNTAX score

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